| 000 -LEADER |
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| fixed length control field |
02017pab a2200397 454500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
150901b1998 xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
Tata Memorial Hospital |
| 041 ## - LANGUAGE CODE |
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| Language code of text/sound track or separate title |
English |
| 082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER |
|---|
| Classification number |
616.155 |
| Item number |
|
| 100 ## - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Bapna A |
| 245 ## - TITLE STATEMENT |
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| Title |
All-trans-retinoic acid (ATRA) : pediatric acute promyelocytic leukemia |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) |
|---|
| Date of publication, distribution, etc. |
1998 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
243-248 |
| 490 ## - SERIES STATEMENT |
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| Series statement |
|
| Volume/sequential designation |
Vol 15 Issues 3 |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
Acute promyelocytic leukemia (APL) is a distinct subtype of acute myeloblastic leukemia (AML). In this report, we present the clinical features, management, and outcome of pediatric patients with APL treated with all-trans-retinoic acid (ATRA). Of 52 newly diagnosed cases of APL between February 1992 and December 1996, 15 were in the pediatric age group (younger than 15 years). Four patients were treated with ATRA alone and 11 were allocated to receive ATRA followed by chemotherapy. Eighty-six percent of the patients achieved a complete response. The patients who received ATRA alone as maintenance therapy had relapses with a median duration of remission of 8 months (range 6-12). The patients who received ATRA, followed by consolidation chemotherapy, had a prolonged duration of remission, with a median of 20 months (range 13-28). In addition, rapid correction of coagulopathy was observed in these patients. The median duration for correction of coagulopathy was 7 days (range 5-11) and the median duration for |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name as entry element |
retinoic acid syndrome, |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name as entry element |
pediatric acute promyelocytic leukemia |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name as entry element |
myeloid leukemia |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name as entry element |
hyperleucocytosis |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name as entry element |
Leukemia |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Gladstone B |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Kadam P |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Nair CN |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Advani SH |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Tapan KS |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Nair R |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
|
| 773 ## - HOST ITEM ENTRY |
|---|
| Host Biblionumber |
78341 |
| Main entry heading |
Pediatric Hematology and Oncology |
| 906 ## - LOCAL DATA ELEMENT F, LDF (RLIN) |
|---|
| a |
May-Jun |
| 907 ## - LOCAL DATA ELEMENT G, LDG (RLIN) |
|---|
| a |
9615322 |
| 907 ## - LOCAL DATA ELEMENT G, LDG (RLIN) |
|---|
| a |
Clinical Trial |
| 907 ## - LOCAL DATA ELEMENT G, LDG (RLIN) |
|---|
| a |
England |
| 907 ## - LOCAL DATA ELEMENT G, LDG (RLIN) |
|---|
| a |
Medical Oncology |
| 907 ## - LOCAL DATA ELEMENT G, LDG (RLIN) |
|---|
| a |
TMC |
| 907 ## - LOCAL DATA ELEMENT G, LDG (RLIN) |
|---|
| a |
TMH |
