Amelioration of cisplatin induced nephrotoxicity in Swiss albino mice by Rubia cordifolia extract (Record no. 30235)

000 -LEADER
fixed length control field 01786pab a2200289 454500
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 150901b2008 xxu||||| |||| 00| 0 eng d
040 ## - CATALOGING SOURCE
Original cataloging agency Tata Memorial Hospital
041 ## - LANGUAGE CODE
Language code of text/sound track or separate title English
082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER
Classification number
Item number
100 ## - MAIN ENTRY--PERSONAL NAME
Personal name Joy J
245 ## - TITLE STATEMENT
Title Amelioration of cisplatin induced nephrotoxicity in Swiss albino mice by Rubia cordifolia extract
260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT)
Date of publication, distribution, etc. 2008
300 ## - PHYSICAL DESCRIPTION
Extent 111-115
490 ## - SERIES STATEMENT
Series statement
Volume/sequential designation Vol 4 Issues 3
520 ## - SUMMARY, ETC.
Summary, etc. Background: Cisplatin is one of the most effective chemotherapeutics against a wide range of cancers including head, neck, ovarian and lung cancers. But its usefulness is limited by its toxicity to normal tissues, including cells of the kidney proximal tubule. The purpose of the present study is to investigate whether the hydro-alcoholic extract of Rubia cordifolia could decrease the intensity of toxicity in Swiss albino mice.
Materials and Methods: Cisplatin at a dose of 12 mg/kg body wt was administered intraperitoneally to Swiss albino mice. Another set of animals was given hydro-alcoholic extract of Rubia cordifolia at different doses along with cisplatin treatment. The antioxidant levels, serum creatinine, serum urea etc. were analyzed.
Results: The extract could significantly decrease the cisplatin induced nephrotoxicity as inferred from the tissue antioxidant status in the drug administered animals. Remarkable change was observed in serum creatinine and urea levels. Lipid peroxidation in the kidney
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element Rubia cordifolia,
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element nephrotoxiciity
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element Cisplatin
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element Antioxidants
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element
700 ## - ADDED ENTRY--PERSONAL NAME
Personal name ckknair@yahoo.com
700 ## - ADDED ENTRY--PERSONAL NAME
Personal name Nair CK
773 ## - HOST ITEM ENTRY
Host Biblionumber 78381
Main entry heading Journal of Cancer Research and Therapeutics
906 ## - LOCAL DATA ELEMENT F, LDF (RLIN)
a Jul-Sep
907 ## - LOCAL DATA ELEMENT G, LDG (RLIN)
a India
907 ## - LOCAL DATA ELEMENT G, LDG (RLIN)
a Original Article
Holdings
Withdrawn status Lost status Damaged status Not for loan Permanent Location Current Location Date acquired Cost, normal purchase price Full call number Barcode Date last seen Price effective from Koha item type
        Tata Memorial Hospital Tata Memorial Hospital 2008-10-15 0.00 AR8592 2015-09-02 2015-09-02 Articles

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