| 000 -LEADER |
|---|
| fixed length control field |
01584pab a2200337 454500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
150901b2014 xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
Tata Memorial Hospital |
| 041 ## - LANGUAGE CODE |
|---|
| Language code of text/sound track or separate title |
English |
| 082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER |
|---|
| Classification number |
|
| Item number |
|
| 100 ## - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Singh RK |
| 245 ## - TITLE STATEMENT |
|---|
| Title |
IGF-1R inhibition potentiates cytotoxic effects of chemotherapeutic agents in early stages of chemoresistant ovarian cancer cells |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) |
|---|
| Date of publication, distribution, etc. |
2014 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
254-262 |
| 490 ## - SERIES STATEMENT |
|---|
| Series statement |
|
| Volume/sequential designation |
Vol 354 Issues 2 |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
The kinetics and effect of hyper activated IGF-1R signaling is not well investigated during acquirement of platinum and taxol resistance in ovarian cancer cells. Herein we reported an upregulated IGF-1R expression in early stages of Cisplatin, and cisplatin-taxol resistance. Picropodophyllin, an IGF-1R inhibitor, alone and in combination with Cisplatin, or both at lowest possible doses could reverse the resistance at early stages. Upregulated IGF-1R was also found in primary tumours of ovarian cancer patients after 3-4 cycles of platinum-taxol treatment. These findings indicate that a combination of cytotoxic agents and IGF-1R inhibitor is more effective at early stages of chemoresistant ovarian cancer. |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name as entry element |
IGF-1R signaling,,,, |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name as entry element |
Ovarian cancer |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name as entry element |
Chemoresistance |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name as entry element |
|
| 700 ## - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Maheshwari A |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Chaudhury S |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Jinager A |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Gaikwad SM |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
|
| 700 ## - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Ray P |
| 773 ## - HOST ITEM ENTRY |
|---|
| Main entry heading |
Cancer Letter |
| 906 ## - LOCAL DATA ELEMENT F, LDF (RLIN) |
|---|
| a |
Aug |
| 907 ## - LOCAL DATA ELEMENT G, LDG (RLIN) |
|---|
| a |
SURGICAL ONCOLOGY-GYNECOLOGIC ONCOLOGY |
| 907 ## - LOCAL DATA ELEMENT G, LDG (RLIN) |
|---|
| a |
TMH |
| 907 ## - LOCAL DATA ELEMENT G, LDG (RLIN) |
|---|
| a |
TMC
|
