IGF-1R inhibition potentiates cytotoxic effects of chemotherapeutic agents in early stages of chemoresistant ovarian cancer cells (Record no. 35327)

000 -LEADER
fixed length control field 01584pab a2200337 454500
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 150901b2014 xxu||||| |||| 00| 0 eng d
040 ## - CATALOGING SOURCE
Original cataloging agency Tata Memorial Hospital
041 ## - LANGUAGE CODE
Language code of text/sound track or separate title English
082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER
Classification number
Item number
100 ## - MAIN ENTRY--PERSONAL NAME
Personal name Singh RK
245 ## - TITLE STATEMENT
Title IGF-1R inhibition potentiates cytotoxic effects of chemotherapeutic agents in early stages of chemoresistant ovarian cancer cells
260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT)
Date of publication, distribution, etc. 2014
300 ## - PHYSICAL DESCRIPTION
Extent 254-262
490 ## - SERIES STATEMENT
Series statement
Volume/sequential designation Vol 354 Issues 2
520 ## - SUMMARY, ETC.
Summary, etc. The kinetics and effect of hyper activated IGF-1R signaling is not well investigated during acquirement of platinum and taxol resistance in ovarian cancer cells. Herein we reported an upregulated IGF-1R expression in early stages of Cisplatin, and cisplatin-taxol resistance. Picropodophyllin, an IGF-1R inhibitor, alone and in combination with Cisplatin, or both at lowest possible doses could reverse the resistance at early stages. Upregulated IGF-1R was also found in primary tumours of ovarian cancer patients after 3-4 cycles of platinum-taxol treatment. These findings indicate that a combination of cytotoxic agents and IGF-1R inhibitor is more effective at early stages of chemoresistant ovarian cancer.
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element IGF-1R signaling,,,,
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element Ovarian cancer
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element Chemoresistance
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element
700 ## - ADDED ENTRY--PERSONAL NAME
Personal name Maheshwari A
700 ## - ADDED ENTRY--PERSONAL NAME
Personal name Chaudhury S
700 ## - ADDED ENTRY--PERSONAL NAME
Personal name Jinager A
700 ## - ADDED ENTRY--PERSONAL NAME
Personal name Gaikwad SM
700 ## - ADDED ENTRY--PERSONAL NAME
Personal name
700 ## - ADDED ENTRY--PERSONAL NAME
Personal name Ray P
773 ## - HOST ITEM ENTRY
Main entry heading Cancer Letter
906 ## - LOCAL DATA ELEMENT F, LDF (RLIN)
a Aug
907 ## - LOCAL DATA ELEMENT G, LDG (RLIN)
a SURGICAL ONCOLOGY-GYNECOLOGIC ONCOLOGY
907 ## - LOCAL DATA ELEMENT G, LDG (RLIN)
a TMH
907 ## - LOCAL DATA ELEMENT G, LDG (RLIN)
a TMC
Holdings
Withdrawn status Lost status Damaged status Not for loan Permanent Location Current Location Date acquired Cost, normal purchase price Full call number Barcode Date last seen Price effective from Koha item type
        Tata Memorial Hospital Tata Memorial Hospital 2014-08-27 0.00 AR15325 2015-09-02 2015-09-02 Articles

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