| 000 -LEADER |
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| fixed length control field |
01464pab a2200241 454500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
150901b2014 xxu||||| |||| 00| 0 eng d |
| 100 ## - MAIN ENTRY--PERSONAL NAME |
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| Personal name |
Singh RK |
| 245 ## - TITLE STATEMENT |
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| Title |
IGF-1R inhibition potentiates cytotoxic effects of chemotherapeutic agents in early stages of chemoresistant ovarian cancer cells |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) |
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| Date of publication, distribution, etc |
2014 |
| 300 ## - PHYSICAL DESCRIPTION |
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| Extent |
|
| 520 ## - SUMMARY, ETC. |
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| Summary, etc |
The kinetics and effect of hyper activated IGF-1R signaling is not well investigated during acquirement of platinum and taxol resistance in ovarian cancer cells. Herein we reported an upregulated IGF-1R expression in early stages of Cisplatin, and cisplatin-taxol resistance. Picropodophyllin, an IGF-1R inhibitor, alone and in combination with Cisplatin, or both at lowest possible doses could reverse the resistance at early stages. Upregulated IGF-1R was also found in primary tumours of ovarian cancer patients after 3-4 cycles of platinum-taxol treatment. These findings indicate that a combination of cytotoxic agents and IGF-1R inhibitor is more effective at early stages of chemoresistant ovarian cancer. |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
IGF-1R signaling, |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name as entry element |
Ovarian cancer |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
Chemoresistance |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Maheshwari A |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Chaudhury S |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Jinager A |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Gaikwad SM |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Ray P |
| 773 ## - HOST ITEM ENTRY |
|---|
| Main entry heading |
Cancer Letter |
| Place, publisher, and date of publication |
Limerick : Elsevier Science Ireland, 2014 |
| Relationship information |
Vol. 354, no.2, p.254-62. |
| International Standard Serial Number |
0304-3835 |
| 906 ## - LOCAL DATA ELEMENT F, LDF (RLIN) |
|---|
| Dept |
SO-Gynae |
| Corporate name |
TMC |
| PMID |
25157649 |
| Article Type |
Journal Article |
| Country type |
International |
| Added Entry |
TMH |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
|
| Item type |
Articles |
