IGF-1R inhibition potentiates cytotoxic effects of chemotherapeutic agents in early stages of chemoresistant ovarian cancer cells (Record no. 38687)

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fixed length control field 01464pab a2200241 454500
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fixed length control field 150901b2014 xxu||||| |||| 00| 0 eng d
100 ## - MAIN ENTRY--PERSONAL NAME
Personal name Singh RK
245 ## - TITLE STATEMENT
Title IGF-1R inhibition potentiates cytotoxic effects of chemotherapeutic agents in early stages of chemoresistant ovarian cancer cells
260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT)
Date of publication, distribution, etc 2014
300 ## - PHYSICAL DESCRIPTION
Extent
520 ## - SUMMARY, ETC.
Summary, etc The kinetics and effect of hyper activated IGF-1R signaling is not well investigated during acquirement of platinum and taxol resistance in ovarian cancer cells. Herein we reported an upregulated IGF-1R expression in early stages of Cisplatin, and cisplatin-taxol resistance. Picropodophyllin, an IGF-1R inhibitor, alone and in combination with Cisplatin, or both at lowest possible doses could reverse the resistance at early stages. Upregulated IGF-1R was also found in primary tumours of ovarian cancer patients after 3-4 cycles of platinum-taxol treatment. These findings indicate that a combination of cytotoxic agents and IGF-1R inhibitor is more effective at early stages of chemoresistant ovarian cancer.
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element IGF-1R signaling,
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element Ovarian cancer
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element Chemoresistance
700 ## - ADDED ENTRY--PERSONAL NAME
Personal name Maheshwari A
700 ## - ADDED ENTRY--PERSONAL NAME
Personal name Chaudhury S
700 ## - ADDED ENTRY--PERSONAL NAME
Personal name Jinager A
700 ## - ADDED ENTRY--PERSONAL NAME
Personal name Gaikwad SM
700 ## - ADDED ENTRY--PERSONAL NAME
Personal name Ray P
773 ## - HOST ITEM ENTRY
Main entry heading Cancer Letter
Place, publisher, and date of publication Limerick : Elsevier Science Ireland, 2014
Relationship information Vol. 354, no.2, p.254-62.
International Standard Serial Number 0304-3835
906 ## - LOCAL DATA ELEMENT F, LDF (RLIN)
Dept SO-Gynae
Corporate name TMC
PMID 25157649
Article Type Journal Article
Country type International
Added Entry TMH
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Source of classification or shelving scheme
Item type Articles
Holdings
Withdrawn status Lost status Damaged status Not for loan Permanent location Current location Date acquired Cost, normal purchase price Full call number Barcode Date last seen Koha item type
        Tata Memorial Hospital Tata Memorial Hospital 2014-08-27 0.00 AR15324 2015-09-02 Articles

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