000 -LEADER |
fixed length control field |
01464pab a2200241 454500 |
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
fixed length control field |
150901b2014 xxu||||| |||| 00| 0 eng d |
100 ## - MAIN ENTRY--PERSONAL NAME |
Personal name |
Singh RK |
245 ## - TITLE STATEMENT |
Title |
IGF-1R inhibition potentiates cytotoxic effects of chemotherapeutic agents in early stages of chemoresistant ovarian cancer cells |
260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) |
Date of publication, distribution, etc |
2014 |
300 ## - PHYSICAL DESCRIPTION |
Extent |
|
520 ## - SUMMARY, ETC. |
Summary, etc |
The kinetics and effect of hyper activated IGF-1R signaling is not well investigated during acquirement of platinum and taxol resistance in ovarian cancer cells. Herein we reported an upregulated IGF-1R expression in early stages of Cisplatin, and cisplatin-taxol resistance. Picropodophyllin, an IGF-1R inhibitor, alone and in combination with Cisplatin, or both at lowest possible doses could reverse the resistance at early stages. Upregulated IGF-1R was also found in primary tumours of ovarian cancer patients after 3-4 cycles of platinum-taxol treatment. These findings indicate that a combination of cytotoxic agents and IGF-1R inhibitor is more effective at early stages of chemoresistant ovarian cancer. |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name as entry element |
IGF-1R signaling, |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name as entry element |
Ovarian cancer |
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
Topical term or geographic name as entry element |
Chemoresistance |
700 ## - ADDED ENTRY--PERSONAL NAME |
Personal name |
Maheshwari A |
700 ## - ADDED ENTRY--PERSONAL NAME |
Personal name |
Chaudhury S |
700 ## - ADDED ENTRY--PERSONAL NAME |
Personal name |
Jinager A |
700 ## - ADDED ENTRY--PERSONAL NAME |
Personal name |
Gaikwad SM |
700 ## - ADDED ENTRY--PERSONAL NAME |
Personal name |
Ray P |
773 ## - HOST ITEM ENTRY |
Main entry heading |
Cancer Letter |
Place, publisher, and date of publication |
Limerick : Elsevier Science Ireland, 2014 |
Relationship information |
Vol. 354, no.2, p.254-62. |
International Standard Serial Number |
0304-3835 |
906 ## - LOCAL DATA ELEMENT F, LDF (RLIN) |
Dept |
SO-Gynae |
Corporate name |
TMC |
PMID |
25157649 |
Article Type |
Journal Article |
Country type |
International |
Added Entry |
TMH |
942 ## - ADDED ENTRY ELEMENTS (KOHA) |
Source of classification or shelving scheme |
|
Item type |
Articles |