432P QTWiST analysis to compare the benefit of maintenance Erlotinib versus pemetrexed patients with EGFR non mutated NSCLC (Record no. 82643)

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fixed length control field 01718nab a22003017a 4500
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fixed length control field 180109b2018 xxu||||| |||| 00| 0 eng d
100 ## - MAIN ENTRY--PERSONAL NAME
Personal name Turkar S
Relator term Corresponding author
245 ## - TITLE STATEMENT
Title 432P QTWiST analysis to compare the benefit of maintenance Erlotinib versus pemetrexed patients with EGFR non mutated NSCLC
260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT)
Date of publication, distribution, etc 2017
300 ## - PHYSICAL DESCRIPTION
Extent
520 ## - SUMMARY, ETC.
Summary, etc Background: In an open label, Phase 3 randomised study, Pemetrexed maintenance after induction with 4-6 cycles of pemetrexed -Platinum therapy failed to prove its superiority over Erlotinib in patients with EGFR non mutated NSCLC. In this analysis we have assessed the benefit of erlotinib over Pemetrexed using quality adjusted time without symptom or toxicity analysis method.

Methods: The overall survival in each arm was partitioned into 3 health states. TOX state (Time spent in grade 3 or above toxicity after randomization and before progression), TWiST state (Time spent after randomization before progression without grade 3 or above toxicity) and REL state (Time spent after progression). The mean QTWiST was calculated for each arm using utility coefficients of 0.65 for TOX, 0.71 for TWiST and 0.67 for REL...
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element mutation
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element non-small-cell lung carcinoma
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element receptor
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element epidermal growth factor
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element pemetrexed
700 ## - ADDED ENTRY--PERSONAL NAME
Personal name Joshi A
700 ## - ADDED ENTRY--PERSONAL NAME
Personal name Noronha V
700 ## - ADDED ENTRY--PERSONAL NAME
Personal name Patil V
700 ## - ADDED ENTRY--PERSONAL NAME
Personal name Sharma M
700 ## - ADDED ENTRY--PERSONAL NAME
Personal name Vora S
700 ## - ADDED ENTRY--PERSONAL NAME
Personal name More S
700 ## - ADDED ENTRY--PERSONAL NAME
Personal name Goud S
700 ## - ADDED ENTRY--PERSONAL NAME
Personal name Prabhash K
773 ## - HOST ITEM ENTRY
Main entry heading Annals of Oncology
Place, publisher, and date of publication London : Oxford University Press, 2017
Relationship information Vol. 28, no. (suppl_10), p.
International Standard Serial Number 0923-7534
906 ## - LOCAL DATA ELEMENT F, LDF (RLIN)
Dept Medical Oncology
Corporate name TMC
Article Type Research Article
Country type International
Added Entry TMH
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Item type Articles
Holdings
Withdrawn status Lost status Source of classification or shelving scheme Damaged status Not for loan Permanent location Current location Date acquired Barcode Date last seen Koha item type
          Tata Memorial Hospital Tata Memorial Hospital 2018-01-09 AR18736 2018-01-09 Articles

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