| 000 -LEADER |
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| fixed length control field |
02637nab a22003137a 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
180813b2018 xxu||||| |||| 00| 0 eng d |
| 100 ## - MAIN ENTRY--PERSONAL NAME |
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| Personal name |
Zanwar S |
| 245 ## - TITLE STATEMENT |
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| Title |
Efficacy of crizotinib in ALK mutant non-small cell lung cancers that are positive by IHC but negative by FISH compared to FISH positive cases |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) |
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| Date of publication, distribution, etc |
2018 |
| 300 ## - PHYSICAL DESCRIPTION |
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| Extent |
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| 500 ## - GENERAL NOTE |
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| General note |
Address for correspondence: kprabhash1@gmail.com |
| 520 ## - SUMMARY, ETC. |
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| Summary, etc |
BACKGROUND: A small proportion of Non-Small Cell Lung Cancers (NSCLC) are detected with Anaplastic Lymphoma Kinase (ALK) mutation by immunohistochemistry (IHC) but are negative by Fluorescence in situ Hybridization (FISH). Data on responses and outcome of this subset of patients when treated with crizotinib is limited. We analyzed the outcomes of such patients who received crizotinib. PATIENTS AND METHODS: Demographics, treatment details, response to treatment, date of progression and date of death were collected for patients who were IHC positive and FISH negative for ALK mutation from a prospectively maintained database. Depending upon feasibility, patients received either platinum based doublet chemotherapy or the ALK inhibitor crizotinib as first line therapy. Outcomes were compared to our previously published historical cohort of FISH positive patients who were treated with crizotinib. RESULTS: Thirteen patients were detected to be IHC+/FISH- and out of these seven received crizotinib. Objective response rate for crizotinib was 57.15% with an estimated mean PFS of 9.6 months (95% CI 3.8 -15.5 months). The difference in ORR of ALK IHC+/FISH- when compared to our historical cohort of ALK FISH positive treated with crizotinib was not statistically significant (57.15% vs 69.8%; P = 0.265). Estimated mean and median PFS was similar between the two cohorts (median PFS 6.0 months vs 14 months; mean PFS 9.6 months versus 14.7 months; P = 0.467). CONCLUSION: NSCLCs positive for ALK mutation by IHC but not detected by FISH show good response to crizotinib and merit treatment with the same. |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
Anaplastic lymphoma kinase positive |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
Crizotinib |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
Fluorescence in situ hybridization |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name as entry element |
Immunohistochemistry |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Noronha V |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Joshi A |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Patil VM |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Kaushal R |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Chougule A |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Janu A |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Mahajan A |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Kapoor A |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| Personal name |
Prabhash K |
| Relator term |
Corresponding author |
| 773 ## - HOST ITEM ENTRY |
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| Main entry heading |
Indian Journal of Cancer |
| Place, publisher, and date of publication |
Mumbai : Medknow Publications, 2017 |
| Relationship information |
Vol. 54, no. 4, p. 678-680 |
| International Standard Serial Number |
0019-509X |
| 906 ## - LOCAL DATA ELEMENT F, LDF (RLIN) |
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| Dept |
Medical Oncology |
| Corporate name |
TMC |
| Article Type |
Original Article |
| Country type |
National |
| Added Entry |
TMH |
| PMID |
30082557 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Item type |
Articles |
