IGF1R predicts better survival in high-grade serous epithelial ovarian cancer patients and correlates with hCtr1 levels. (Record no. 83818)

000 -LEADER
fixed length control field 01825nab a2200301 4500
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 190612b2019 xxu||||| |||| 00| 0 eng d
100 ## - MAIN ENTRY--PERSONAL NAME
Personal name Deo A
245 ## - TITLE STATEMENT
Title IGF1R predicts better survival in high-grade serous epithelial ovarian cancer patients and correlates with hCtr1 levels.
260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT)
Date of publication, distribution, etc 2019
300 ## - PHYSICAL DESCRIPTION
Extent
500 ## - GENERAL NOTE
General note Address for correspondence: pray@actrec.gov.in
520 ## - SUMMARY, ETC.
Summary, etc Aim: To evaluate the potential of IGF1R as a prognostic marker for high-grade serous ovarian cancer (HGSOC) patients. Patients & methods: The expression levels of IGF1R and drug transporters (ABCB1, hCtr1) were measured longitudinally in chemo-naive and chemo-treated tumor samples from 19 HGSOC patients, and their correlation with the clinical outcome was examined. Results: IGF1R expression was significantly upregulated in treated tumor samples, which positively correlated with hCtr1 levels. Patients with metastatic tumors with IGF1R expression higher than median showed better overall survival (median not reached) and disease-free survival (26.7 months) than those with less than median expression (overall survival: 27.5 months [p = 0.029]; disease-free survival: 11.9 months [p = 0.014]). Conclusion: IGF1R prognosticates prolonged survival in HGSOC patients, possibly due to its positive correlation with hCtr1.
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element HGSOC
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element IGF1R
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element hCtr1
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element Neoadjuvant chemotherapy
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element Ovarian cancer
650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name as entry element Prognostic marker
700 ## - ADDED ENTRY--PERSONAL NAME
Personal name Chaudhury S
700 ## - ADDED ENTRY--PERSONAL NAME
Personal name Kannan S
700 ## - ADDED ENTRY--PERSONAL NAME
Personal name Rekhi B
700 ## - ADDED ENTRY--PERSONAL NAME
Personal name Maheshwari A
700 ## - ADDED ENTRY--PERSONAL NAME
Personal name Gupta S
700 ## - ADDED ENTRY--PERSONAL NAME
Personal name Ray P
773 ## - HOST ITEM ENTRY
Main entry heading Biomarkers in Medicine
Place, publisher, and date of publication London : Future Medicine, 2019
Relationship information Vol. 13, no. 07, p. 511-521.
International Standard Serial Number 1752-0363
906 ## - LOCAL DATA ELEMENT F, LDF (RLIN)
Dept Pathology
Corporate name TMC
PMID 31140856
Article Type Journal Article
Country type International
Added Entry TMH
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Source of classification or shelving scheme
Item type Articles
Holdings
Withdrawn status Lost status Source of classification or shelving scheme Damaged status Not for loan Permanent location Current location Date acquired Barcode Date last seen Koha item type
          Tata Memorial Hospital Tata Memorial Hospital 2019-06-12 AR19475 2019-06-12 Articles

Powered by Koha