Beyond conventional chemotherapy, targeted therapy and immunotherapy in squamous cell cancer of the oral cavity (Record no. 84580)

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fixed length control field 01926nab a22002777a 4500
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fixed length control field 200421b2020 xxu||||| |||| 00| 0 eng d
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Personal name Patil VM
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Title Beyond conventional chemotherapy, targeted therapy and immunotherapy in squamous cell cancer of the oral cavity
260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT)
Date of publication, distribution, etc 2020
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Extent
500 ## - GENERAL NOTE
General note Address for correspondence: kumarprabhashtmh@gmail.com
520 ## - SUMMARY, ETC.
Summary, etc The focus of this review article is to throw light on non-conventional systemic chemotherapy that affects the tumour microenvironment and potentially has a favourable impact on the management of squamous cell cancer of the oral cavity. A metronomic combination of weekly methotrexate and celecoxib seems equally effective to single agent cisplatin in the palliative setting, but needs phase III testing. The same metronomic combination seems inferior to paclitaxel-cetuximab. Triple drug metronomic chemotherapy (methotrexate, celecoxib, and erlotinib) is still under development with promising data from pilot studies. Metronomic chemotherapy also seems beneficial in the curative setting but results of confirmatory studies are eagerly awaited. The low rate of adverse events and low cost make this regimen an attractive alternative. Both in vivo and in-vitro data suggests that numerous drugs like anthelmintics, DMARDs, antimalarials can be repurposed for Head and Neck Cancers. However, there is a dearth of clinical studies reported till date.
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Topical term or geographic name as entry element Head and Neck Cancer
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Topical term or geographic name as entry element Metronomic chemotherapy
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Topical term or geographic name as entry element Oral cancer
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Topical term or geographic name as entry element Repurposed
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Personal name Noronha V
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Personal name Joshi A
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Personal name Abhyankar A
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Personal name Menon N
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Personal name Dhumal S
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Personal name Prabhash K
Relator term Corresponding author
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Main entry heading Oral Oncology.
Place, publisher, and date of publication Amsterdam : Elsevier, 2020
Relationship information Vol. 105, p. 104673.
International Standard Serial Number 1368-8375
906 ## - LOCAL DATA ELEMENT F, LDF (RLIN)
Dept SO-Head & Neck
Corporate name TMC
PMID 32272385
Article Type Journal Article
Country type International
Added Entry TMH - HBNI
First Author TMH - HBNI
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Item type Articles
Holdings
Withdrawn status Lost status Source of classification or shelving scheme Damaged status Not for loan Permanent location Current location Date acquired Barcode Date last seen Koha item type
          Tata Memorial Hospital Tata Memorial Hospital 2020-04-21 AR20022 2020-04-21 Articles

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