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Hepatitis B vaccination in acute lymphoblastic leukemia

In Leukemia Research
By: Goyal S.
Contributor(s): Advani SH | Kelkar R | Pai SK | .
Material type: materialTypeLabelArticleSeries: Vol 22 Issues 2.Publisher: 1998Description: 193-195.Subject(s): poor seroconversion | immunosuppression | hepatitis B vaccination | ALL | LeukemiaDDC classification: 616.155 In: Leukemia ResearchSummary: Active immunization against hepatitis B virus infection was carried out in 162 patients with acute lymphoblastic leukemia attending the Outpatient Department at Tata Memorial Hospital. Recombinant DNA vaccine was given in three doses at 0, 1 and 2 months followed by a booster 1 year after the first dose. Antibodies to hepatitis B surface antigen could be detected in 19.7% of patients following vaccination. Of these only 10.5% had titers in the protective range. Immunosuppression induced by both disease and treatment appears to diminish responsiveness to vaccination. Passive active prophylaxis with both vaccine and immunoglobulin may be a more effective alternative in these patients
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Articles Articles Tata Memorial Hospital
616.155 Available AR1188

Active immunization against hepatitis B virus infection was carried out in 162 patients with acute lymphoblastic leukemia attending the Outpatient Department at Tata Memorial Hospital. Recombinant DNA vaccine was given in three doses at 0, 1 and 2 months followed by a booster 1 year after the first dose. Antibodies to hepatitis B surface antigen could be detected in 19.7% of patients following vaccination. Of these only 10.5% had titers in the protective range. Immunosuppression induced by both disease and treatment appears to diminish responsiveness to vaccination. Passive active prophylaxis with both vaccine and immunoglobulin may be a more effective alternative in these patients

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