Neoadjuvant chemotherapy with Ifosfamide and Cisplatin combination in advanced head and neck cancer: a retrospective analysis of 519 patients: a single institution experience
In Medical Oncology
Contributor(s): Parikh PM | Mistry RC | Bakshi AV | Parikh DM | Mazumdar, Alaka T | Deshmukh C | Pathak KA | drvrpai@rediffmail.com | Pai VR.
Material type:
ArticleSeries: Vol 20 Issues 1.Publisher: 2003Description: 1-5.Subject(s): Cancer | Head and neck | Chemotherapy | DDC classification:
In:
Medical OncologySummary: Advanced head and neck cancer is a major therapeutic problem in India. Ifosfamide has shown significant activity as a single agent in head and neck squamous carcinoma. In this study, we present our experience with two cycles of ifosfamide and cisplatin in the neoadjuvant setting given to a total of 519 patients. The complete response rate was 20% and the overall response rate was 80%. The treatment was well tolerate, there was no need for dose reduction, and there were no life-threatening side effects. We feel that this high response rate is sufficient to warrant more studies using ifosfamide-based combinations in a neoadjuvant setting for squamous carcinoma of the head and neck.
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Advanced head and neck cancer is a major therapeutic problem in India. Ifosfamide has shown significant activity as a single agent in head and neck squamous carcinoma. In this study, we present our experience with two cycles of ifosfamide and cisplatin in the neoadjuvant setting given to a total of 519 patients. The complete response rate was 20% and the overall response rate was 80%. The treatment was well tolerate, there was no need for dose reduction, and there were no life-threatening side effects. We feel that this high response rate is sufficient to warrant more studies using ifosfamide-based combinations in a neoadjuvant setting for squamous carcinoma of the head and neck.
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