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In vitro resistance of leukaemic blasts to prednisolone in bcr-abl positive childhood acute lymphoblastic leukemia

In Indian Journal of Medical Research
By: Gupta M.
Contributor(s): Anil K | .
Material type: materialTypeLabelArticleSeries: Vol 116 Issues 6.Publisher: 2002Description: 268-272.Subject(s): Acute Lymphoblastic LeukemiaDDC classification: In: Indian Journal of Medical ResearchSummary: Although the outcome of children with ALL( Acute Lymphoblastic Leukemia) has improved dramatically over the last decade,some children still poorly and relapses are seen.Laukaemic blasts of ber-abl positive children with ALL are about four-fold resistant to prednisolone as compared to blasts from ber-abl negative children. This suggests that one of the reasons for the poor prognosis of ber-abl positive ALL could be a lower steroid sensitivity.
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Although the outcome of children with ALL( Acute Lymphoblastic Leukemia) has improved dramatically over the last decade,some children still poorly and relapses are seen.Laukaemic blasts of ber-abl positive children with ALL are about four-fold resistant to prednisolone as compared to blasts from ber-abl negative children. This suggests that one of the reasons for the poor prognosis of ber-abl positive ALL could be a lower steroid sensitivity.

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