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Age related macular degeneration: A study of patients managed with radiotherapy

In Journal of Cancer Research and Therapeutics
Contributor(s): Dinshaw KA | Dudhani A | Sarin R | anusheel8@ hotmail.com | Munshi A.
Material type: materialTypeLabelArticleSeries: Vol 3 Issues 1.Publisher: 2007Description: 12-16.Subject(s): India | Radiotherapy | Age-related macular degeneration | DDC classification: In: Journal of Cancer Research and TherapeuticsSummary: Introduction: Age-related macular degeneration (ARMD) is the leading cause of blindness in the west. Radiotherapy affects the evolution of exudative macular degeneration directly by its effect on the endothelium and inflammation modulation. We conducted a retrospective study to evaluate the improvement in visual acuity and healing of sub retinal neovascular membrane (SRNV) following fractionated radiotherapy. Materials and Methods: 47 patients (58 eyes) of ARMD were retrospectively analyzed. One of the following radiotherapy fractionation schedules was employed in all the patients in this study. a) 15 Gy /5 fractions/1 week (five patients) b) 20 Gy/5 fractions/1 week (19 patients) c) 22.5Gy/5 fractions/1 week (21 patients) d) 25 Gy/5 fractions/1 week (two patients). VA and funduscopy was taken at each follow-up for objective improvement and to assess the healing of SRNV. Results: The median follow-up was 7.23 months. The mean improvement in the VA in the entire group was of 0.44 line. (Median 1, SD 1.04). O
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Introduction: Age-related macular degeneration (ARMD) is the leading cause of blindness in the west. Radiotherapy affects the evolution of exudative macular degeneration directly by its effect on the endothelium and inflammation modulation. We conducted a retrospective study to evaluate the improvement in visual acuity and healing of sub retinal neovascular membrane (SRNV) following fractionated radiotherapy. Materials and Methods: 47 patients (58 eyes) of ARMD were retrospectively analyzed. One of the following radiotherapy fractionation schedules was employed in all the patients in this study. a) 15 Gy /5 fractions/1 week (five patients) b) 20 Gy/5 fractions/1 week (19 patients) c) 22.5Gy/5 fractions/1 week (21 patients) d) 25 Gy/5 fractions/1 week (two patients). VA and funduscopy was taken at each follow-up for objective improvement and to assess the healing of SRNV. Results: The median follow-up was 7.23 months. The mean improvement in the VA in the entire group was of 0.44 line. (Median 1, SD 1.04). O

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