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Cancer risks among BRCA1 and BRCA2 mutation carriers

In British Journal of Cancer
Contributor(s): Friedman E | lahad@szmc.org.il | Levy-Lahad E.
Material type: materialTypeLabelArticleSeries: Vol 96 Issues 1.Publisher: 2007Description: 11-15.Subject(s): Israel | ovarian cancer | breast cancer | penetrance | BRCA2 | BRCA1 | DDC classification: In: British Journal of CancerSummary: BRCA1 and BRCA2 mutations increase breast and ovarian cancer risks substantially enough to warrant risk reduction surgery, despite variable risk estimates. Underlying this variability are methodological issues, and also complex genetic and nongenetic effects. Although many modifying factors are unidentified, known factors can already be incorporated in individualised risk prediction.
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BRCA1 and BRCA2 mutations increase breast and ovarian cancer risks substantially enough to warrant risk reduction surgery, despite variable risk estimates. Underlying this variability are methodological issues, and also complex genetic and nongenetic effects. Although many modifying factors are unidentified, known factors can already be incorporated in individualised risk prediction.

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