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Electrochemotherapy in treatment of tumours

In European Journal of Surgical Oncology.
By: Sersa G.
Contributor(s): Pucihar G | Rudolf Z | Cemazar M | Miklavcic D | msnoj@onko-i.si | Snoj M.
Material type: materialTypeLabelArticleSeries: Vol 34 Issues 2.Publisher: 2008Description: 232-240.Subject(s): Cutaneous tumours | Cisplatin | Bleomycin | Electrochemotherapy | Electroporation | DDC classification: In: European Journal of Surgical OncologySummary: Aim Electrochemotherapy is a local drug delivery approach aimed at treatment with palliative intent of cutaneous and subcutaneous tumour nodules of different histologies. Electrochemotherapy, via cell membrane permeabilising electric pulses, potentiates the cytotoxicity of non-permeant or poorly permeant anticancer drugs with high intrinsic cytotoxicity, such as bleomycin or cisplatin, at the site of electric pulse application. Methods An overview of preclinical and clinical studies is presented, and the treatment procedure is further critically evaluated. Results In clinical studies electrochemotherapy has proved to be a highly efficient and safe approach for treating cutaneous and subcutaneous tumour nodules. The treatment response for various tumours (predominantly melanoma) was 75% complete and 10% partial response of the treated nodules. Conclusions Electrochemotherapy is a new, clinically acknowledged method for the treatment of cutaneous and subcutaneous tumours. Its advantages are high effec
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Aim
Electrochemotherapy is a local drug delivery approach aimed at treatment with palliative intent of cutaneous and subcutaneous tumour nodules of different histologies. Electrochemotherapy, via cell membrane permeabilising electric pulses, potentiates the cytotoxicity of non-permeant or poorly permeant anticancer drugs with high intrinsic cytotoxicity, such as bleomycin or cisplatin, at the site of electric pulse application.
Methods
An overview of preclinical and clinical studies is presented, and the treatment procedure is further critically evaluated. Results
In clinical studies electrochemotherapy has proved to be a highly efficient and safe approach for treating cutaneous and subcutaneous tumour nodules. The treatment response for various tumours (predominantly melanoma) was 75% complete and 10% partial response of the treated nodules.
Conclusions
Electrochemotherapy is a new, clinically acknowledged method for the treatment of cutaneous and subcutaneous tumours. Its advantages are high effec

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