Integrated PET/CT in evaluating sarcomatous transformation in osteochondromas
In Clinical Nuclear Medicine
By: Purandare NC.
Contributor(s): Paraskar S | Arora A | Shah S | Sharma AR | Agarwal M | Rangarajan V | drvrangarajan@gmail.com.
Material type:
ArticleSeries: Vol 34 Issues 6.Publisher: 2009Description: 350-354.Subject(s): | HME | CT | PET | Osteochondroma | DDC classification:
In:
Clinical Nuclear MedicineSummary: Aim: To study the role of PET-CT in evaluating sarcomatous transformation in osteochondromas.
Materials and Methods: This was a retrospective analysis of a prospective data base of 12 patients from 2005 to 2007 with a clinical diagnosis of an osteocartilaginous lesion who were referred for a FDG PET-CT study to evaluate for possible malignant transformation. Imaging was performed on a GE Discovery ST PET-CT system after intravenous injection of 370 MBq (10 mCi) of F-18 FDG.
Results: Seven patients with histopathological evidence of a sarcomatous transformation to grade II chondrosarcoma showed moderate to high FDG uptake (SUV 3.3-6.9), whereas 1 patient with a dedifferentiated chondrosarcoma showed a focus of very intense uptake (SUV 11.4). Four patients with histopathological and/or clinical or follow-up diagnosis of a benign osteocartilaginous lesion showed low grade FDG uptake (SUV 0.8-1.3). FDG uptake was also noted in an asymptomatic osteochondroma which on histopathology revealed a grade II chon
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Tata Memorial Hospital | Available | AR9357 |
Aim: To study the role of PET-CT in evaluating sarcomatous transformation in osteochondromas.
Materials and Methods: This was a retrospective analysis of a prospective data base of 12 patients from 2005 to 2007 with a clinical diagnosis of an osteocartilaginous lesion who were referred for a FDG PET-CT study to evaluate for possible malignant transformation. Imaging was performed on a GE Discovery ST PET-CT system after intravenous injection of 370 MBq (10 mCi) of F-18 FDG.
Results: Seven patients with histopathological evidence of a sarcomatous transformation to grade II chondrosarcoma showed moderate to high FDG uptake (SUV 3.3-6.9), whereas 1 patient with a dedifferentiated chondrosarcoma showed a focus of very intense uptake (SUV 11.4). Four patients with histopathological and/or clinical or follow-up diagnosis of a benign osteocartilaginous lesion showed low grade FDG uptake (SUV 0.8-1.3). FDG uptake was also noted in an asymptomatic osteochondroma which on histopathology revealed a grade II chon
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