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Cytomegalovirus infection in six neonates

In Indian Pediatrics
By: Yadav S.
Contributor(s): Biswas S | Gupta S | Narayan S | drgauravnarula@gmail.com | Narula G.
Material type: materialTypeLabelArticleSeries: Vol 47 Issues 2.Publisher: 2009Description: 174-175.Subject(s): Indian | Neonate | Management | Ganciclovir | CMV | DDC classification: Online resources: Click here to access online In: Indian PediatricsSummary: Neonatal cytomegalovirus (CMV) infection is common, has myriad presentations and severe sequelae. Six neonates clinically suspected of CMV infection were confirmed by qualitative PCR (Digene) and evaluated. Those with persistent viremia were treated with Ganciclovir intravenously for 4-6 weeks, and continued orally if required with close monitoring. All had prolonged jaundice, hepatosplenomegaly and hematological manifestations in the acute stage. Complications included developmental delay (66 %), sensorineural hearing loss (SNHL) (33 %), chorioretinitis and obstructive jaundice (18 % each). Three cleared viremia spontaneously. The remaining were offered Ganciclovir. One declined, and two completed therapy with clinical resolution and no adverse events. Accurate diagnosis of neonatal CMV enables appropriate treatment with Ganciclovir, which can reverse end-organ damage and limit sequelae.
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Articles Articles Tata Memorial Hospital
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Neonatal cytomegalovirus (CMV) infection is common, has myriad presentations and severe sequelae. Six neonates clinically suspected of CMV infection were confirmed by qualitative PCR (Digene) and evaluated. Those with persistent viremia were treated with Ganciclovir intravenously for 4-6 weeks, and continued orally if required with close monitoring. All had prolonged jaundice, hepatosplenomegaly and hematological manifestations in the acute stage. Complications included developmental delay (66 %), sensorineural hearing loss (SNHL) (33 %), chorioretinitis and obstructive jaundice (18 % each). Three cleared viremia spontaneously. The remaining were offered Ganciclovir. One declined, and two completed therapy with clinical resolution and no adverse events. Accurate diagnosis of neonatal CMV enables appropriate treatment with Ganciclovir, which can reverse end-organ damage and limit sequelae.

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