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Clinical characteristics and outcome of nodular lymphocyte predominant hodgkin lymphoma in children - a single centre experience

In Pediatric Blood and Cancer
Contributor(s): Banavali S | Laskar S | Sengar M | Menon H | Nair R | Arora B | Nahar A | | Prasad M.
Material type: materialTypeLabelArticleSeries: Vol 57 Issues 5.Publisher: 2011Description: 776.Subject(s): DDC classification: In: Pediatric Blood and CancerSummary: Purpose: Nodular Lymphocyte Predominant Hodgkin Lymphoma (NLPHL) is a distinct subtype of Hodgkin Lymphoma (HL). The optimal treatment strategy in children is unknown. Most studies report excellent event-free survival, with overall survival rates approaching 100%.We provide a retrospective analysis of the clinical characteristics and outcome of 18 pediatric NLPHL patients from our center. Method: A retrospective analysis was performed on patients 015 years of age with NLPHL presenting to Tata Memorial Hospital (TMH), Mumbai, from January 2001 to April 2010.The diagnosis was confirmed by expert pathologists based on histology and staining criteria. Results: Out of 650 HL patients, 21(3.2%) had NLPHL. 20 were males and 1 female. The median age was 9 years (range 614 years). Data was available on 18 patients: 7 had early stage disease (3 stage I, 4 stage II), of which one had bulk disease. All received 46 cycles ABVD. 11 patients had advanced stage disease (10 stage III, 1 stage IV), of whom three pre
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Articles Articles Tata Memorial Hospital
(Browse shelf) Available AR12069

Purpose: Nodular Lymphocyte Predominant Hodgkin Lymphoma (NLPHL) is a distinct subtype of Hodgkin Lymphoma (HL). The optimal treatment strategy in children is unknown. Most studies report excellent event-free survival, with overall survival rates approaching 100%.We provide a retrospective analysis of the clinical characteristics and outcome of 18 pediatric NLPHL patients from our center.

Method: A retrospective analysis was performed on patients 015 years of age with NLPHL presenting to Tata Memorial Hospital (TMH), Mumbai, from January 2001 to April 2010.The diagnosis was confirmed by expert pathologists based on histology and staining criteria.

Results: Out of 650 HL patients, 21(3.2%) had NLPHL. 20 were males and 1 female. The median age was 9 years (range 614 years). Data was available on 18 patients: 7 had early stage disease (3 stage I, 4 stage II), of which one had bulk disease. All received 46 cycles ABVD. 11 patients had advanced stage disease (10 stage III, 1 stage IV), of whom three pre

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