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2 CdA in the treatment of hairy cell leukaemia

In Journal of Association of Physicians of India
By: Abhyankar D.
Contributor(s): Advani SH | Nair CN | Gopal R | Saikia T | Bajpai S | .
Material type: materialTypeLabelArticleSeries: Vol 49 Issues.Publisher: 2001Description: 785-777.Subject(s): Splenectomy | Hairy cell | Leukaemia | DDC classification: In: Journal of Association of Physicians of IndiaSummary: INTRODUCTION: Hairy cell leukaemia (HCL) is a rare lymphoproliferative disorder. Treatment options available are splenectomy, interferon, DCF and 2-CdA. 2-CdA is considered to have curative potential as proved by the other studies. METHODS: We gave 2-CdA in a dose of 0.09/kg/day as a continuous infusion in sixteen patients of hairy cell leukaemia. RESULTS: Three patients developed neutropenia post transfusion. At the end of three months all patients were in remission. Two patients relapsed at the median follow-up of 15 months. CONCLUSION: 2-CdA in HCL can achieve complete remission, prolonged survival and care as well.
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INTRODUCTION: Hairy cell leukaemia (HCL) is a rare lymphoproliferative disorder. Treatment options available are splenectomy, interferon, DCF and 2-CdA. 2-CdA is considered to have curative potential as proved by the other studies.

METHODS: We gave 2-CdA in a dose of 0.09/kg/day as a continuous infusion in sixteen patients of hairy cell leukaemia.

RESULTS: Three patients developed neutropenia post transfusion. At the end of three months all patients were in remission. Two patients relapsed at the median follow-up of 15 months.

CONCLUSION: 2-CdA in HCL can achieve complete remission, prolonged survival and care as well.

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