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Oral metronomic scheduling of anticancer therapy-based treatment compared to existing standard of care in locally advanced oral squamous cell cancers: a matched-pair

In Indian Journal of Cancer
By: Pai PS.
Contributor(s): Banavali SD | Prabhash K | Vaidya AD | banavali_2000@yahoo.com.
Material type: materialTypeLabelArticleSeries: Vol 50 Issues 2.Publisher: 2013Subject(s): Oral cancers | Metronomic | Chemotherapy | DDC classification: In: Indian Journal of CancerSummary: CONTEXT: Head and neck cancers in developing countries present with advanced disease, compounded by poor access to tertiary care centers. AIM: We evaluated oral metronomic scheduling of anticancer therapy (MSAT) in advanced operable oral cancers, in conjunction with standard therapy. SETTINGS AND DESIGN: This was a retrospective matched-pair analysis carried out in a tertiary referral cancer center. MATERIALS AND METHODS: Advanced operable oral cancer patients having a waiting period for surgery > 3 weeks were administered MSAT. Patients then underwent standard therapy (surgery +/- adjuvant radiation/chemoradiation) as warranted by the disease, followed by MSAT maintenance therapy. Outcomes of the MSAT group were compared with stage-matched controls with similar waiting periods. STATISTICAL ANALYSIS: Survivals were found using the Kaplan-Meier method and compared between groups using the log rank test. RESULTS: Response was seen in 75% of 32 patients. Two-year disease-free survivals (DFS) in
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Articles Articles Tata Memorial Hospital
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CONTEXT: Head and neck cancers in developing countries present with advanced disease, compounded by poor access to tertiary care centers.

AIM: We evaluated oral metronomic scheduling of anticancer therapy (MSAT) in advanced operable oral cancers, in conjunction with standard therapy.

SETTINGS AND DESIGN: This was a retrospective matched-pair analysis carried out in a tertiary referral cancer center.

MATERIALS AND METHODS: Advanced operable oral cancer patients having a waiting period for surgery > 3 weeks were administered MSAT. Patients then underwent standard therapy (surgery +/- adjuvant radiation/chemoradiation) as warranted by the disease, followed by MSAT maintenance therapy. Outcomes of the MSAT group were compared with stage-matched controls with similar waiting periods.

STATISTICAL ANALYSIS: Survivals were found using the Kaplan-Meier method and compared between groups using the log rank test.

RESULTS: Response was seen in 75% of 32 patients. Two-year disease-free survivals (DFS) in

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