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Primary mediastinal seminoma; resistance and relapse: an aggressive entity

In Indian Journal of Medical and Paediatric Oncology
By: Nachankar A.
Contributor(s): Noronha V | Joshi A | Krishnatry R | agarwaljp@tmc.gov.in | Agarwal JP.
Material type: materialTypeLabelArticleSeries: Vol 34 Issues 4.Publisher: 2013Description: 309-312.Subject(s): Soft-tissue metastasis | Radio-resistance | Mediastinal seminoma | Extra-gonadal germ cell tumor | Chemoresistance | Bone metastasis | DDC classification: In: Indian Journal of Medical and Paediatric OncologySummary: Seminoma is one of the most radio and chemo sensitive tumors. Aggressive variant of primary mediastinal seminoma (PMS) are rarely described in the literature. We here discuss an interesting case of young male (22 years) presenting with superior vena cava syndrome due to PMS that showed poor response to conventional platinum based chemotherapy and radiotherapy. Furthermore, with a short disease free interval (one year) relapsed at unusual sites of bone and soft-tissue deposits in check. This emphasizes the importance of identifying methods to pre-screen such aggressive variants for more effective treatment options.
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Seminoma is one of the most radio and chemo sensitive tumors. Aggressive variant of primary mediastinal seminoma (PMS) are rarely described in the literature. We here discuss an interesting case of young male (22 years) presenting with superior vena cava syndrome due to PMS that showed poor response to conventional platinum based chemotherapy and radiotherapy. Furthermore, with a short disease free interval (one year) relapsed at unusual sites of bone and soft-tissue deposits in check. This emphasizes the importance of identifying methods to pre-screen such aggressive variants for more effective treatment options.

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