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Accelerated versus conventional fractionated radiotherapy in squamous cell carcinoma of the head and neck (SCCHN). a randomized international multicenter trial with 908 patients conducted by the IAEA-ACC study group

In International Journal of Radiation Oncology Biology Physics
By: Overgaard J.
Contributor(s): Grau C | Vikram B | Baeza M | Kuddu M | Agerwal J | Ali R | Begum N | Bhasker S | Mohanti B | .
Material type: materialTypeLabelArticleSeries: Vol 66 Issues 3.Publisher: 2006Description: s13.Subject(s): DDC classification: In: International Journal of Radiation Oncology Biology PhysicsSummary: Purpose/Objective(s): Several large randomized studies have shown that accelerated fractionation may be beneficial in the radiotherapy treatment of SCCHN These studies have been performed in Europe and USA, and it is unclear to which extend such treatment principle can be generalized to radiotherapy practice in the developing world where the therapeutic resources are less and the patients have a more heavy tumor burden. In order to test the applicability of these results in a global setting, the International Atomic Energy Agency (IAEA) initiated a two-armed randomised multicentre trial. The aim of the study was to examine whether reduction of the overall treatment time by increasing the number of weekly fractions from 5 to 6 (and maintaining same total dose and fx number) would improve the tumor response, and were acceptable with regard to early and late morbidity, as well as being a suitable therapeutic principle in all therapeutic environments. Materials/Methods: Patients with SCC of the larynx, phary
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Purpose/Objective(s): Several large randomized studies have shown that accelerated fractionation may be beneficial in the
radiotherapy treatment of SCCHN These studies have been performed in Europe and USA, and it is unclear to which extend
such treatment principle can be generalized to radiotherapy practice in the developing world where the therapeutic resources are less and the patients have a more heavy tumor burden. In order to test the applicability of these results in a global setting, the International Atomic Energy Agency (IAEA) initiated a two-armed randomised multicentre trial. The aim of the study was to examine whether reduction of the overall treatment time by increasing the number of weekly fractions from 5 to 6 (and maintaining same total dose and fx number) would improve the tumor response, and were acceptable with regard to early and late morbidity, as well as being a suitable therapeutic principle in all therapeutic environments.
Materials/Methods: Patients with SCC of the larynx, phary

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