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Myoepithelioma of parotid: A case report and review of literature

In Journal of Oral Research and Review
Contributor(s): Kumar HS | Kumar V | Beniwal S | Bagri PK | Rajpu PS | kapoorakhil1987@gmail.com | Kapoor A.
Material type: materialTypeLabelArticleSeries: Vol 6 Issues 2.Publisher: 2014Description: 53-56.Subject(s): Histopathology, immunohistochemistry, myoepithelioma, parotid | DDC classification: In: Journal of Oral Research and ReviewSummary: Myoepithelioma (ME) is a rarely encountered tumor of salivary gland accounting for about 1% of all salivary gland tumors. Though they were first identified long back, still their histopathologic features and immunohistochemistry (IHC) profile are not well characterized and there is no definitive criterion for this tumor with complex and varied features remaining a major barrier. We present a case of parotid enlargement in an 18-year-old girl in whom the IHC studies of superficial parotidectomy specimen revealed positive staining for Cytokeratin 5/6, HMW CK, Smooth muscle actin (SMA), S100, calponin, vimentin, and p63. CD45, EMA, CK7, carcinoembryonic antigen (CEA), BerEP4, GCDFP-15, and Glial fibrillary acidic protein (GFAP)-stained negative. With these IHC findings, the diagnosis of ME of parotid was established. This report highlights the importance of IHC studies along with a brief review of the literature
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Myoepithelioma (ME) is a rarely encountered tumor of salivary gland accounting for about 1% of all salivary gland tumors. Though they were first identified long back, still their histopathologic features and immunohistochemistry (IHC) profile are not well characterized and there is no definitive criterion for this tumor with complex and varied features remaining a major barrier. We present a case of parotid enlargement in an 18-year-old girl in whom the IHC studies of superficial parotidectomy specimen revealed positive staining for Cytokeratin 5/6, HMW CK, Smooth muscle actin (SMA), S100, calponin, vimentin, and p63. CD45, EMA, CK7, carcinoembryonic antigen (CEA), BerEP4, GCDFP-15, and Glial fibrillary acidic protein (GFAP)-stained negative. With these IHC findings, the diagnosis of ME of parotid was established. This report highlights the importance of IHC studies along with a brief review of the literature

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