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The effect of anticoagulants on cancer risk and survival: Systematic review

In Cancer treatment reviews
Contributor(s): Kahn SR | Robinson-Cohen C | Blostein M | vicky.tagalakis@mcgill.ca | Tagalakis V.
Material type: materialTypeLabelArticleSeries: Vol 33 Issues 3.Publisher: 2007Description: 358-368.Subject(s): Canada | Mortality | Prevention | Therapy | Cancer | Warfarin | Low molecular weight heparin | DDC classification: In: Cancer treatment reviewsSummary: Objectives Several in vitro and in vivo studies have shown that low molecular weight heparin and warfarin may directly inhibit tumour cell growth and prevent metastatic spread. However, the clinical evidence in support of an anti-cancer effect is less conclusive. We summarize the evidence from clinical studies that examine the effect of these anticoagulants on cancer development and briefly describe the current understanding of the potential mechanisms by which anticoagulants may exert an anti-cancer effect. Methods English-language articles reporting on warfarin, coumarin or low molecular weight heparin for the treatment or prevention of cancer were selected from PUBMED. All randomized clinical trials, case-control studies, cohort studies, and meta-analyses were retrieved. Detailed data review and abstraction was performed according to pre-specified criteria. Results Of ninety-nine articles retrieved, 12 warfarin and 17 low molecular weight heparin articles were included in the review. We fo
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Objectives

Several in vitro and in vivo studies have shown that low molecular weight heparin and warfarin may directly inhibit tumour cell growth and prevent metastatic spread. However, the clinical evidence in support of an anti-cancer effect is less conclusive. We summarize the evidence from clinical studies that examine the effect of these anticoagulants on cancer development and briefly describe the current understanding of the potential mechanisms by which anticoagulants may exert an anti-cancer effect.

Methods

English-language articles reporting on warfarin, coumarin or low molecular weight heparin for the treatment or prevention of cancer were selected from PUBMED. All randomized clinical trials, case-control studies, cohort studies, and meta-analyses were retrieved. Detailed data review and abstraction was performed according to pre-specified criteria.

Results

Of ninety-nine articles retrieved, 12 warfarin and 17 low molecular weight heparin articles were included in the review. We fo

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