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T2 weighted MRI in assessment of volume changes during radiotherapy of high grade gliomas

In Journal of Cancer Research and Therapeutics
Contributor(s): Mekala C | Trivedi N | Huilgol NG | dr_divya22@rediffmail.com | Shukla D.
Material type: materialTypeLabelArticleSeries: Vol 1 Issues 4.Publisher: 2005Description: 235-238.Subject(s): Tumor volumes | High grade gliomas | Radiotherapy | DDC classification: In: Journal of Cancer Research and TherapeuticsSummary: Aim: To determine whether any changes in gross tumor volume occur between pre treatment MRI and week 5 MRI in high grade gliomas treated by conformal radiotherapy. Methods and Materials: Between july 2003-july 2005, 17 patients with WHO grades 3 and 4 malignant gliomas treated with conformal radiotherapy to a total dose of 60 Gy were included in this retrospective study. All patients had undergone T2 weighted MRI a day before treatment and then again at end of week 5 of treatment for definition of initial and boost fields respectively. Gross tumor volumes were delineated on the two MRIs of each patient and the differences were noted. Two patients with multifocal disease were excluded from the final analysis. Results: Of the 15 patients with unifocal disease, 12/15 cases (80%) showed a reduction in tumor volumes (median 54.85 cc). Of these, 4/15(26.6%) cases (two each of grade 3 and grade 4 gliomas) had an objective reduction in GTV (>=50%) and 3/ 15(20%) cases (two of grade 4 and one of grade 3 gliomas)
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Articles Articles Tata Memorial Hospital
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Aim: To determine whether any changes in gross tumor volume occur between pre treatment MRI and week 5 MRI in high grade
gliomas treated by conformal radiotherapy. Methods and Materials: Between july 2003-july 2005, 17 patients with WHO grades 3 and 4 malignant gliomas treated with conformal radiotherapy to a total dose of 60 Gy were included in this retrospective study. All patients had undergone T2 weighted MRI a day before treatment and then again at end of week 5 of treatment for definition of initial and boost fields respectively. Gross tumor volumes were delineated on the two MRIs of each patient and the differences were noted. Two patients with multifocal disease were excluded from the final analysis.
Results: Of the 15 patients with unifocal disease, 12/15 cases (80%) showed a reduction in tumor volumes (median 54.85 cc). Of these, 4/15(26.6%) cases (two each of grade 3 and grade 4 gliomas) had an objective reduction in GTV (>=50%) and 3/ 15(20%) cases (two of grade 4 and one of grade 3 gliomas)

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