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Comparison of 2 contouring methods of bone marrow on CT and correlation with hematological toxicities in non-bone marrow-sparing pelvic intensity-modulated radiotherapy with concurrent cisplatin for cervical cancer

In International Journal of Gynecological Cancer
By: Mahantshetty U.
Contributor(s): Shrivastava S | Chopra S | Engineer R | Kanaujia A | Chaudhari S | Krishnatry R | .
Material type: materialTypeLabelArticleSeries: Vol 22 Issues 8.Publisher: 2012Description: 1427-1434.Subject(s): Cervical cancer | Cisplatin | Radiotherapy | Hematological toxicity | CT | Bone marrow | DDC classification: In: International Journal of Gynecological CancerSummary: OBJECTIVES: To compare volumes and dose volume histogram (DVH) parameters for bone marrow contours using 2 methods on computed tomography (CT) and correlation with grade 2 or higher hematological toxicity (HT) in patients with cervical cancer treated with non-bone marrow-sparing intensity-modulated radiotherapy (IMRT) with concurrent cisplatin. MATERIALS AND METHODS: The planning CT scans of 47 patients prospectively enrolled and treated with IMRT arm of a phase 2 trial (NCT00193804) contoured for pelvic bone marrow in 2 sets; whole bone (WB), and freehand (FH) inner cavity of bone. Various subvolumes were made in each set-sacrum, ilium, ischium, lower pelvis, lumbosacral spine, sacrum, and whole pelvis-and compared for volume and DVH parameters (V10, V20, V30, and V40) using paired t test. The hematological parameters during RT compiled from electronic database analyzed for higher than grade 2 (Radiation Therapy Oncology Group) HT and correlated with DVH parameters using log regression analysis (P < 0.0
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OBJECTIVES: To compare volumes and dose volume histogram (DVH) parameters for bone marrow contours using 2 methods on computed tomography (CT) and correlation with grade 2 or higher hematological toxicity (HT) in patients with cervical cancer treated with non-bone marrow-sparing intensity-modulated radiotherapy (IMRT) with concurrent cisplatin.

MATERIALS AND METHODS: The planning CT scans of 47 patients prospectively enrolled and treated with IMRT arm of a phase 2 trial (NCT00193804) contoured for pelvic bone marrow in 2 sets; whole bone (WB), and freehand (FH) inner cavity of bone. Various subvolumes were made in each set-sacrum, ilium, ischium, lower pelvis, lumbosacral spine, sacrum, and whole pelvis-and compared for volume and DVH parameters (V10, V20, V30, and V40) using paired t test. The hematological parameters during RT compiled from electronic database analyzed for higher than grade 2 (Radiation Therapy Oncology Group) HT and correlated with DVH parameters using log regression analysis (P < 0.0

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