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Loss of chromosome Y in acute lymphoblastic leukemia: age related or neoplastic phenomenon?

In Indian Journal of Pathology and Microbiology
By: Gupta A.
Contributor(s): Remani AS | mayur.parihar@tmckolkata.com | Parihar M.
Material type: materialTypeLabelArticleSeries: Vol 57 Issues 3.Publisher: 2014Description: 431-434.Subject(s): Acquired abnormality, B-lymphoblastic leukemia, loss of chromosome Y, pediatric | DDC classification: Online resources: Click here to access online In: Indian Journal of Pathology and MicrobiologySummary: Loss of chromosome Y (LOY) in the bone marrow has long been considered as an age-related phenomenon with an incidence of more than 25% in males beyond the age of 80 years. Though reported as an acquired abnormality in myeloid neoplasms, it has rarely been described in B-lymphoblastic leukemia which primarily is a disease of the young. We describe here in three cases of pediatric B-lymphoblastic leukemia with LOY. Conventional cytogenetic studies and fluorescence in situ hybridization studies using centromeric probes for chromosome X and Y on peripheral blood samples ruled out constitutional LOY in all the three cases favoring it to be a neoplastic phenomenon.
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Loss of chromosome Y (LOY) in the bone marrow has long been considered as an age-related phenomenon with an incidence of more than 25% in males beyond the age of 80 years. Though reported as an acquired abnormality in myeloid neoplasms, it has rarely been described in B-lymphoblastic leukemia which primarily is a disease of the young. We describe here in three cases of pediatric B-lymphoblastic leukemia with LOY. Conventional cytogenetic studies and fluorescence in situ hybridization studies using centromeric probes for chromosome X and Y on peripheral blood samples ruled out constitutional LOY in all the three cases favoring it to be a neoplastic phenomenon.

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