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Cytogenetic Profile in 7209 Indian Patients with de novo Acute Leukemia: A Single Centre Study from India

In Journal of Cancer Therapy
By: Kadam Amare PS [Corresponding author].
Contributor(s): H Jain | Kabre S | Deshpande Y | Pawar P | Banavali S | Menon H | Sengar M | Arora B | Khattry N | Narula G | Sarang D | Kaskar S | Bagal B | Jain H | Dang U | Subramanian PG | Gujral S.
Material type: materialTypeLabelArticlePublisher: Irvine, Calif : Scientific Research Publishing, Inc 2016Description: .Subject(s): Cytogenetics | Acute Leukemia | Incidence | Asian Population | Geographic HeterogeneityOnline resources: PDF In: Journal of Cancer Therapy Vol. no., p.530-544Summary: Background: Cytogenetics is one of the most important diagnostic parameters in the classification of acute leukemia. Recurrent chromosomal aberrations in acute leukemia have provided insights into the molecular mechanism of leukemogenesis. The variable frequencies of recurrent cytogenetic markers due to ethical/racial differences have been reported from Western and some Asian countries. Objective: We report cytogenetic data of largest cohort of 7209 adult and pediatric patients with de novo acute leukemia (AL) to determine the prevalence of various cytogenetic sub groups and compare with the Western and Asian population. Material & Methods: The AL patients included 2609 AML (adult: 2042, pediatric: 567), 3708 B-cell-precursor (BCP)-ALL (adult: 1300, pediatric: 2408) and 892 cases of T-ALL (adult: 480, pediatric: 412). Cytogenetic studies included conventional karyotyping and FISH using panel of probes. Results: The incidence of t(8;21) was high, comparable to other Asian countries. In comparison to our series and Western population, t(15;17) was more prevalent in Chinese population. Cytogenetic profiling of BCP-ALL revealed low prevalence of ETV6/RUNX1 in ours as well as other Asian population. The MLL aberrations in BCP-ALL and TLX1 & TLX3 aberrations in T-ALL occurred less frequently in our series as compared with Western population. Conclusion: The present study with a large cohort showed the heterogeneity of AL that involved various factors, such as age, gender and prevalence of distinct cytogenetic subgroups. Our data in comparison with other population based studies revealed differential distribution of some cytogenetic sub-groups indicating geographic heterogeneity due to differential environmental exposure which probably influenced underlying genetic susceptibility.
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Address for Correspondence: pratibha.amare@gmail.com

Background: Cytogenetics is one of the most important diagnostic parameters in the classification
of acute leukemia. Recurrent chromosomal aberrations in acute leukemia have provided insights
into the molecular mechanism of leukemogenesis. The variable frequencies of recurrent cytogenetic
markers due to ethical/racial differences have been reported from Western and some Asian
countries. Objective: We report cytogenetic data of largest cohort of 7209 adult and pediatric patients
with de novo acute leukemia (AL) to determine the prevalence of various cytogenetic sub
groups and compare with the Western and Asian population. Material & Methods: The AL patients
included 2609 AML (adult: 2042, pediatric: 567), 3708 B-cell-precursor (BCP)-ALL (adult: 1300,
pediatric: 2408) and 892 cases of T-ALL (adult: 480, pediatric: 412). Cytogenetic studies included
conventional karyotyping and FISH using panel of probes. Results: The incidence of t(8;21) was
high, comparable to other Asian countries. In comparison to our series and Western population,
t(15;17) was more prevalent in Chinese population. Cytogenetic profiling of BCP-ALL revealed low
prevalence of ETV6/RUNX1 in ours as well as other Asian population. The MLL aberrations in
BCP-ALL and TLX1 & TLX3 aberrations in T-ALL occurred less frequently in our series as compared
with Western population. Conclusion: The present study with a large cohort showed the heterogeneity
of AL that involved various factors, such as age, gender and prevalence of distinct cytogenetic
subgroups. Our data in comparison with other population based studies revealed differential
distribution of some cytogenetic sub-groups indicating geographic heterogeneity due to differential
environmental exposure which probably influenced underlying genetic susceptibility.

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