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337O Quality of life without toxicity or symptoms analysis of a randomized controlled clinical trial comparing efficacy of Cabazitaxel versus docetaxel in recurrent Head and Neck Cancer

In Annals of Oncology
By: Talreja VT.
Contributor(s): Patil V | Joshi A | Noronha V | Chandrasekharan A | Dhumal S | Pande N | Turkar S | Shrirangwar S | Mahajan A | Juvrekar S | Bhattacharjee A | Prabhash K.
Material type: materialTypeLabelArticlePublisher: 2017Description: .Subject(s): Head and neck cancer | Excluding thyroid In: Annals of OncologySummary: Background: This analysis was done with the aim to study the overall impact of docetaxel and cabazitaxel treatment by using quality of life without toxicity or symptoms (QTWiST) analysis in head and neck cancer patients receiving second line treatment Methods: OS (Overall survival) was partitioned in three health states for QTWiST analysis.TOX state was defined as the cumulative number of days spent in grade 3 or above toxicity post randomization and before progression.TWiST state was defined as the cumulative number of days spent post randomization and before progression without grade 3 or above toxicity. REL state was defined as the time spent in days post progression till death. A threshold utility analysis was performed. The difference in mean QTWiST scores with its 95% CI and corresponding p...
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Articles Articles Tata Memorial Hospital
Available AR18668

Background: This analysis was done with the aim to study the overall impact of docetaxel and cabazitaxel treatment by using quality of life without toxicity or symptoms (QTWiST) analysis in head and neck cancer patients receiving second line treatment

Methods: OS (Overall survival) was partitioned in three health states for QTWiST analysis.TOX state was defined as the cumulative number of days spent in grade 3 or above toxicity post randomization and before progression.TWiST state was defined as the cumulative number of days spent post randomization and before progression without grade 3 or above toxicity. REL state was defined as the time spent in days post progression till death. A threshold utility analysis was performed. The difference in mean QTWiST scores with its 95% CI and corresponding p...

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