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Surgical Management of Anaplastic Thyroid Cancers

In Kapre, M.L. (Eds). Thyroid Surgery: Principles and Practice. Boca Raton : CRC Press
By: Nair, D.
Contributor(s): Shetty, R.
Material type: materialTypeLabelArticlePublisher: Boca Raton CRC Press 2020Description: p. 130-133.Subject(s): Anaplastic thyroid carcinoma (ATC) | Thyroid cancer | PET CECT | Chemotherapy | Radiotherapy | Surgical | Survival In: Kapre, M.L. (Eds). Thyroid Surgery: Principles and Practice. Boca Raton : CRC PressSummary: Anaplastic thyroid carcinoma (ATC) are uncommon but account for a significant number of thyroid cancer deaths. They are one of the most lethal tumors in humans, predominantly seen in the elderly. ATC is characterized by rapid disease progression, and early diagnosis remains paramount for initiating treatment to achieve meaningful results. PET CECT is recommended to assess the disease. Surgical extirpation should be considered whenever feasible. Combined modality treatment including surgery and radiotherapy with or without chemotherapy has been shown to improve survival in surgically resectable disease. Radiotherapy or chemotherapy alone may not be curative, however, it has shown to improve survival. Integration of targeted therapy in the multimodality management of anaplastic thyroid cancer needs to be further investigated to design an optimal treatment strategy to deal with aggressive tumors.
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Anaplastic thyroid carcinoma (ATC) are uncommon but account for a significant number of thyroid cancer deaths. They are one of the most lethal tumors in humans, predominantly seen in the elderly. ATC is characterized by rapid disease progression, and early diagnosis remains paramount for initiating treatment to achieve meaningful results. PET CECT is recommended to assess the disease. Surgical extirpation should be considered whenever feasible. Combined modality treatment including surgery and radiotherapy with or without chemotherapy has been shown to improve survival in surgically resectable disease. Radiotherapy or chemotherapy alone may not be curative, however, it has shown to improve survival. Integration of targeted therapy in the multimodality management of anaplastic thyroid cancer needs to be further investigated to design an optimal treatment strategy to deal with aggressive tumors.

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