000 01464pab a2200241 454500
008 150901b2014 xxu||||| |||| 00| 0 eng d
100 _aSingh RK
245 _aIGF-1R inhibition potentiates cytotoxic effects of chemotherapeutic agents in early stages of chemoresistant ovarian cancer cells
260 _c2014
300 _a
520 _aThe kinetics and effect of hyper activated IGF-1R signaling is not well investigated during acquirement of platinum and taxol resistance in ovarian cancer cells. Herein we reported an upregulated IGF-1R expression in early stages of Cisplatin, and cisplatin-taxol resistance. Picropodophyllin, an IGF-1R inhibitor, alone and in combination with Cisplatin, or both at lowest possible doses could reverse the resistance at early stages. Upregulated IGF-1R was also found in primary tumours of ovarian cancer patients after 3-4 cycles of platinum-taxol treatment. These findings indicate that a combination of cytotoxic agents and IGF-1R inhibitor is more effective at early stages of chemoresistant ovarian cancer.
650 _a IGF-1R signaling,
650 _a Ovarian cancer
650 _aChemoresistance
700 _aMaheshwari A
700 _aChaudhury S
700 _aJinager A
700 _aGaikwad SM
700 _aRay P
773 _aCancer Letter
_dLimerick : Elsevier Science Ireland, 2014
_gVol. 354, no.2, p.254-62.
906 _aSO-GY
942 _2ddc
999 _c38687